In one recent study, treatment with the small molecule inhibitor, SGC0946, which targets DOT1L, a histone methyltransferase that catalyzes methylation at the H3K79 position, reduced H3K79 methylation and down-regulated MYCN, ODC1, and E2F2 genes, reducing NB cell proliferation [45]. This evidence concerns the gene MYCN and neuroblastoma.