A critical role for β-catenin in MLL rearranged leukemias prompted us to investigate this triple tyrosine to phenylalanine mutant, CDC73-Y290/293/315F (CDC73_3YF) (Figure 1A) in MLL-AF9 transformed AML cells (Figure 1B) [48–50]. This evidence concerns the gene KMT2A and acute myeloid leukemia.