NME2 and myopathy: Defects in the FHL1 gene are associated with myopathy [50], (4) several proteins in our differentially expressed protein lists may be involved with DNA binding and transcription regulation, including the histone proteins Hist2h2bb and Hist2h4 (differentially expressed in both gastrocnemius and soleus muscle), and Nme2 (earlier discussed in the context of GTP synthesis and downregulated in both gastrocnemius and cardiac muscles) is a transcriptional activator of the MYC gene and can also bind DNA non-specifically [51, 52].