Although we have shown that inhibitory effects of SIK2 on these tumor-related processes e.g., proliferation and invasion, may involve ERK and Akt pathways as potential downstream mediators, further rescue experiments involving modulation of SIK2 and perturbation of these pathways are required to validate SIK2 as a key regulator of these pathways contributing to the observed phenotypic effects. This evidence concerns the gene AKT1 and neoplasm.