In this study, we aimed to clarify the role of HPC markers in the heterogeneity of HCC manifestations by assessing the expression of four HPC markers, EpCAM, NCAM, DLK1, and CK19, in resected HCC tissues by immunohistochemistry and analysing their correlation with clinicopathological characteristics of HCC patients and their potential as prognostic factors for HCC patients after surgery. This evidence concerns the gene EPCAM and hepatocellular carcinoma.