Our results indicate that EpCAM expression together with serum DCP, age, and C-P scores can serve as an independent prognostic factor for patients after HCC resection and that the level of serum tumour markers AFP and AFP-L3 can predict the expression of HPC markers in HCC, thus serving as a non-invasive diagnostic method. The gene discussed is EPCAM; the disease is hepatocellular carcinoma.