On the contrary, other signaling molecules as well as p53, p27, paxillin and HSP27 resulted hyper-phosphorylated in CP-CML CD34+ cells as compared to the normal CD34+ cells, but only p53 (Ser15) reached statistical significance (p = 0.047). This evidence concerns the gene CD34 and chronic myelogenous leukemia, BCR-ABL1 positive.