Our finding about the lower phosphorylation of four kinases belonging to Src family (Lck, Lyn, Fyn, Yes) in the CP of the disease is intriguing, since previous observations reported increased expression and phosphorylation of members of Src family in patients with CML in BC, evoking its role as possible mechanisms of resistance to TKI, independent from BCR-ABL [15, 36–38]. The gene discussed is YES1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.