Diaz-Blanco et al. [22], examining the genome-wide gene expression signature of highly enriched CD34+ cells from CP-CML patient, found that CP-CML CD34+ cells compared to normal CD34+ cells were characterized by a higher expression level of proliferation-associated genes (components of Raf/MEK/ERK1/2 and PI3K/AKT/mTOR pathway and some genes of the JNK and p38 MAPK pathways) [22]. This evidence concerns the gene AKT1 and chronic myelogenous leukemia, BCR-ABL1 positive.