Although they used unsorted CML samples, Kornblau and colleagues reported that several proteins (HSP90, Rb, AIF, PP2A, Bcl-2, Xiap, Smad1, SSBP2a, PARP, Gab2, and TRIM24) were overexpressed in advanced-phase CML patients, as compared with those in CP [32]. This evidence concerns the gene RB1 and chronic myelogenous leukemia, BCR-ABL1 positive.