Results revealed that CD34+ cells from CP-CML, as compared to normal CD34+ cells, are characterized by: 1) lower expression of catalase (p = 0.012), an enzyme that protects cells from the toxic effects of hydrogen peroxide and promotes growth of normal and neoplastic cells including myeloid leukemia cells; 2) higher expression of FADD (p = 0.038), a death receptor involved in extrinsic apoptosis and necroptosis, and of HSP70 (p < 0.001), crucial for cells survival after toxic stimuli (Figure 2). The gene discussed is CAT; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.