PCSK6 and congestive heart failure: Moreover, PCSK6 mRNA levels were elevated in lungs of decompensated CHF rats, as compared to compensated CHF (1.32 ± 0.08 vs. 1.10 ± 0.046, respectively; P < 0.01) and sham-operated animals (1.32 ± 0.08 vs. 1.00 ± 0.0258, P < 0.01) (Figure 5C).