In fact, most of the studies about SOD2 expression and cancer have shown that overexpression of this enzyme is associated with the presence of metastases and poor prognosis in many malignancies, such as lymphomas [28, 29], glioblastoma [30], bladder [31], lung [32], colorectal [33], breast [34], penile [35], gastric [36], esophageal [37] and oral cancer [38]. The gene discussed is SOD2; the disease is lip and oral cavity carcinoma.