Sunitinib was found to reduce the expression of IL-10, Foxp3, PD-1, CTLA4, and BRAF, but increased Th1 cytokine (IFN-γ) in isolated tumor-infiltrating lymphocytes (TILs) in an MCA26 (colon cancer cells) bearing mouse model. The gene discussed is CTLA4; the disease is neoplasm.