In line with our findings, Valmori et al. reported a functional and structural longitudinal analysis of the TCR of circulating CD8 T cells specific for the HLA-A2-restricted immunodominant epitope from the melanocyte differentiation Ag Melan-A in a melanoma patient who developed a vigorous and sustained Ag-specific T cell response following vaccination with the corresponding synthetic peptide. The gene discussed is CD8A; the disease is melanoma.