FOXP3 and rheumatoid arthritis: That Foxp3+ Tregs and B10 Bregs are increased in frequency coordinately inside the MLN following BM-DC and AS-ODN BM-DC administration (which produce RA) leads us to propose a model whereby DC are central in converting T-cells and B-cells into suppressive cells which then migrate into the inflamed colon structures to prevent or attenuate inflammation.