Finally, several epitopes from autoimmunity-related antigens are overrepresented when HLA-DM is entirely absent, such as the epitope GTKVVLDDKDYFLFR from the mitochondrial heat-shock protein HSPE1 and ITSIVKDSSAARN from Syntenin-1 (33, 34). Here, HLA-DMA is linked to Autoimmunity.