Although the levels of only three dominantly proinflammatory molecules, IFN-γ, IP-10, and RANTES, were significantly higher in acute ZIKV infection in the endemic area, they appear to be sufficient for generating an effective antiviral response (26–28), once the subjects usually present viral clearance, at least in the peripheral blood and urine (29). Here, CCL5 is linked to Zika virus infectious disease.