In HT-29 and HCT116 colorectal cancer cells, NEU3 silencing significantly reduced clonogenicity and downregulated stemness and Wnt-related genes, suggesting that Wnt signaling contributes to NEU3-induced tumorigenesis through maintenance of stem-like characteristics of these cells (Takahashi et al., 2015). Here, NEU3 is linked to colorectal cancer.