Several experimental rodent models have been developed to study various contributing factors to diabetic cardiomyopathy; including several genetically modified models; db/db mice, ob/ob mice, Otsuka Long-Evans Tokushima (OLETF) rats, CIRKO (cardiomyocyte deletion of insulin receptor) mice, cardiac lipotoxic mice [cardiomyocyte-specific long-chain acyl-CoA synthetase (ACS) and fatty acid transport protein (FATP1) overexpressing], Zucker diabetic fatty (ZDF), Zucker obese (ZO), lean (ZL) rats, and various other diet-induced obesity (DIO) strains. This evidence concerns the gene SLC27A1 and diabetic cardiomyopathy.