INS and cardiomyopathy: In further support of the ambiguity, a review by Holscher et al. (2016) reported that “instead of being a cardiomyopathy in the classical sense though, diabetic cardiomyopathy represents a combination of molecular myocardial abnormalities that predispose for the development of myocardial dysfunction.” Additional questions regarding diabetic cardiomyopathy and its progression in both insulin-dependent and insulin-independent diabetic patients remain unanswered.