In addition, pancEts-1 interacts with non-POU domain containing octamer binding (NONO) protein to facilitate its binding to Ets related gene (ERG), resulting in increased transactivation of ERG, transcription of Ets-1, and promotion of the in vitro and in vivo growth and aggresiveness of gastric cancer cells, suggesting the crucial roles of pancEts-1/NONO/ERG/Ets-1 axis in gastric cancer progression. This evidence concerns the gene ETS1 and gastric cancer.