Furthermore, we analyzed the correlation between KLF5, GCN5, GDF15, or C5aR expression and clinic-pathological parameters of the 185 NSCLC patients, and found that the expression of these proteins was tightly linked with the tumor size, lymph node metastasis, and TNM stage, but not related to tumor type, patient age and sex (Supplementary Tables 3 to 6). The gene discussed is C5AR1; the disease is neoplasm.