KLF5 and non-small cell lung carcinoma: In vivo, we demonstrated delayed growth and proliferation in nude mice xenograft tumors created by inoculating A549 cells stably infected with LV-shKLF5, LV-shGCN5, or LV-shGDF15, indicating that KLF5, GCN5 and GDF15 are necessary in the maintenance of NSCLC growth.