In vivo, we demonstrated delayed growth and proliferation in nude mice xenograft tumors created by inoculating A549 cells stably infected with LV-shKLF5, LV-shGCN5, or LV-shGDF15, indicating that KLF5, GCN5 and GDF15 are necessary in the maintenance of NSCLC growth. Here, GDF15 is linked to non-small cell lung carcinoma.