In an individual of Arab descent (A4967-21) with SRNS and a biopsy showing focal segmental glomerulosclerosis (FSGS) (Fig. 1e), we identified two compound heterozygous mutations, p.Glu180Ala and p.Lys1358Thr, in DLC1 (Fig. 1f, Supplementary Table 1, Supplementary Fig. 1C). Here, DLC1 is linked to focal segmental glomerulosclerosis.