Cell death-inducing activity of the EGFR-targeted IgG-scTRAIL fusion proteins in comparison to a non-targeted, hexavalent variant of the Fc-scTRAIL format (Fc-scTRAIL-FAVSGAA) was analysed in vitro using the EGFR+ tumour cell lines Colo205, HCT116 (both colon carcinoma) and WM1366 (malignant melanoma)20 (Fig. 3, Table 3). This evidence concerns the gene EGFR and melanoma.