Mutations destabilizing RPE65 (retinoid isomerase), ATP-binding cassette subfamily A member 4 (ABCA4), or rhodopsin (rod visual pigment) are associated with inherited retinal degenerations including Leber congenital amaurosis2,3, Stargardt disease4,5, or adRP6,7, respectively (RetNet, http://www.sph.uth.tmc.edu/RetNet/). The gene discussed is RHO; the disease is retinal degeneration.