On the basis of our proposed sequence of events (Fig. 7), it may be possible to prevent lymphedema by inhibiting CD4+ T cell migration into lymph nodes, activation of CD4+ T cells in lymph nodes, emigration of activated CD4+ T cells out of lymph nodes, the adhesion molecules that guide translocation of CD4+ T cells from the circulation, the chemokine gradients that mediate CD4+ T cell skin-homing, or the effects of CD4+ T cells already in the skin. Here, CD4 is linked to lymphedema.