At the novel menopause locus at 4q23, the nearest gene EIF4E encodes a key translation initiation factor; EIF4E is the target of the inhibitory binding protein encoded by EIF4EBP1, which is near to a known European ancestry menopause locus7, while a rare deleterious stop mutation in EIF4ENIF1, which encodes a nucleocytoplasmic shuttle protein for EIF4E, segregates with primary ovarian insufficiency (menopause at ~30 years old) in a large kindred20. This evidence concerns the gene EIF4ENIF1 and menopause.