MX2 and glioblastoma: To assess the impact of MxB expression on HSV-1 infection, we transfected T98G glioblastoma cells known to express high levels of MxB in response to type I IFN46 (see also Supplementary Fig. 1a) with non-targeting control small interfering RNA (siRNA) (siNT) and MX2-targeting siRNAs (siMxB 3'-untranslated region (UTR), siMxB #1).