Fifty to sixty percent of these cases have genetic origins5, 6 and, of those, close to 70% are nonsyndromic hearing loss.1, 7 Mutations in the GJB2 gene encoding the gap junction β-2 protein, connexin 26, are the most common cause of genetic nonsyndromic hearing loss in different parts of the world.8 The gene discussed is GJB2; the disease is nonsyndromic deafness.