Ipilimumab, the anti- cytotoxic T lymphocyte antigen 4 (anti-CTLA-4) antibody, was FDA-approved in 2015 for the adjuvant treatment of resected stage III melanoma, though it is infrequently used in the adjuvant setting due to its unfavorable side effect profile [4]. The gene discussed is CTLA4; the disease is melanoma.