Therefore, we performed a randomized, placebo-controlled, double-blind trial investigating the effect of the DPP-4 inhibitor linagliptin on endothelial function and further biochemical markers of vascular function and effects on postprandial lipids of the DPP-4 inhibitor linagliptin in early stages of T2DM. The gene discussed is DPP4; the disease is type 2 diabetes mellitus.