Overexpression of Orai1 potentiates the expression of ICAM-1 and VCAM-1 [191], silencing of TRPC1 attenuates cisplatin-induced ICAM-1 expression and endothelial dysfunction [192] and overexpression of TRPC3 enhances TNFα-induced VCAM-1 expression. The gene discussed is ICAM1; the disease is endothelial dysfunction.