SPNS2 and colitis: The pathophysiological relevance of Spns2-mediated S1P secretion was recently reported by Donoviel et al. [19] who used Spns2-deficient mice in various disease models including airway inflammation and hypersensitivity, dextran sulfate sodium-induced colitis, collagen-induced arthritis, and experimental autoimmune encephalomyelitis, and described a strong reduction of disease parameters.