In this regard, ischemia/reperfusion-induced liver injury in mice that leads not only to liver injury, but also to acute kidney injury, was accompanied by a reduction of plasma S1P and dihydro-S1P levels, and application of either S1P or dihydro-S1P acting through S1P1 was shown to reduce systemic inflammation and protect mice from liver and kidney injury [54,55]. The gene discussed is S1PR1; the disease is acute kidney injury.