For example, in the case of CML, with one of the most commercially successful oncogene-targeted therapies so far, the data from Sca1-BCR-ABLp210 animal models showed that the survival of CML stem cells was independent on the kinase activity of BCR-ABL, therefore indicating that curative approaches in CML should most probably focus on kinase-independent mechanisms of resistance [15]. This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.