CML is a paradigmatic stem-cell-driven cancer in humans, but we reasoned that, assuming the tumoral reprogramming theory as we have previously mentioned, a similar experimental approach as the one used to model BCR-ABLp210+ CML could also be used to reproduce in the mouse the genotype-phenotype correlation (specific oncogene/specific tumor) found in other human cancers. This evidence concerns the gene BCR and chronic myelogenous leukemia, BCR-ABL1 positive.