Consistent with the observed exacerbation of acute CHIKV infection, serum C-reactive protein (CRP) concentration was high only in the chloroquine-treated group at 4 dpi (p < 0.05 M&W), possibly indicating the presence of a stronger infection-related inflammation (Figure 2D), despite the reported anti-inflammatory properties of chloroquine (for review, Solomon and Lee [24]). The gene discussed is CRP; the disease is infection.