In contrast, other studies have shown that deletion of 24 amino acids in the E1A gene and with the tripeptide Arg-Gly-Asp (Delta-24-RGD), an OAd whose infectivity in cancer cells is enhanced through the insertion of a RGD-4C motif in the high affinity (HI) loop of the adenoviral fiber protein, and OBP-405, an OAd regulated by the human telomerase reverse transcriptase promoter (hTERT-Ad, OBP-301) with a tropism modification (RGD), induced the autophagic cell death of glioblastoma cells, whereas autophagy inhibitors did not affect the replication of Delta-24-RGD and OBP-405 [36,37]. This evidence concerns the gene DHTKD1 and cancer.