IFIH1 and infection: MAVS is associated with the outer mitochondrial membrane (OMM) and transduces downstream signaling that culminates in the production of type I interferons (IFNs) and pro-inflammatory cytokines upon RIG-like receptors (RLRs, RIG-I—retinoic acid-inducible gene I, MDA-5—melanoma differentiation-associated protein 5) and the binding of pathogen-associated molecular patterns such as dsRNA or ssRNA during infection [7].