INS and diabetes mellitus: However, when was considered each aspect of the diabetes treatment, the comparison between serum insulin levels and wound healing rates showed significant homogeneities in all reported symptoms and presented a large SMD between the two groups ((SMD = 1.92, 95% CI (1.10, 2.75), I2 = 0%) and (SMD = 3.55, 95% CI (2.56, 4.54), I2 = 40%), respectively).