Ren et al. confirmed that B-Myb expression is significantly increased in colorectal cancer (CRC) tissues compared to adjacent noncancerous tissues; that B-Myb overexpression is an independent prognostic factor for worse survival in colorectal cancer patients, as evidenced by Cox multivariate analysis; and that functional analysis showed that downregulation of B-Myb expression suppressed cell proliferation and motility, restricted cell cycle progression, and induced apoptosis [13]. The gene discussed is MYBL2; the disease is colorectal cancer.