PDK3 and melanoma: Moreover, RNA-seq analysis showed that knockdown of B-Myb leads to upregulation of different downstream genes such as IGFBP3 and downregulation of various downstream genes such as COL11A1, FLT4, SPARC, IDH2, and PDK3. Previous reports showed that SPARC promotes cancer development in some cancers with highly metastatic characteristics, including melanoma and breast cancer [36,37], and was uncovered as the potential prognostic marker in several cancer types [38,39,40].