Several lines of evidence have shown that the transcription factor, nuclear factor-kappa B (NF-κB), is a critical determinant, as it regulates a variety of pathophysiological processes, such as inflammation, cell survival, proliferation, invasion, apoptosis, differentiation, and chemo-resistance in different tumor cells, including colorectal [43,44]. The gene discussed is NFKB1; the disease is neoplasm.