A recent study showed that variations in colorectal cancer-related genes (ATF1 and DUSP10) were significantly associated with TA (albeit in isolated cases); further, Atf1 and Dusp10 expression was detected in the mouse developing teeth from early bud stages to the formation of the complete tooth, suggesting a potential role for these genes and their encoded proteins in toothdevelopment [123]. The gene discussed is ATF1; the disease is colorectal cancer.