Consistent with this, by inducible conditional transgenesis authors have demonstrated that codeletion of Tsc1 and Pten in postnatal neural stem cells is necessary for the development of SENs and SEGAs closely resembling human TSC lesions highlighting the relevance of both Akt and mTORC2 pathways for the induction of these tumors [87]. Here, AKT1 is linked to tuberous sclerosis.