Comparing the C-indices of the models with the biomarker GDF-15 to the base models for HF 0.819 (95% CI: 0.788; 0.850) and for death from CHD 0.838 (95% CI: 0.807; 0.869), the p-value for death from CHD was significant (p = 0.0097). The gene discussed is GDF15; the disease is coronary artery disorder.