The longitudinal measurements of GDF-15 were positively associated with death of CHD (HR per IQR 3.02 95% CI: (2.26, 4.04), p < 0.001) and HF (HR per IQR 2.12 95% CI: (1.54, 2.92), p < 0.001). The gene discussed is GDF15; the disease is coronary artery disorder.