GDF15 and hydrops fetalis: Cox regression models revealed significantly increased hazard ratios (HR) for GDF-15 for incident HF (1.36 per IQR increase, 95% confidence interval (CI): 1.16; 1.59) and death from CHD (1.51 per IQR increase, 95% CI: 1.31, 1.75) (both with p-value <0.001) (Fig 2).