APP and Dravet syndrome: Similarly, there were significant differences between APPdup, DS, missense APP mutations, sEOAD and sLOAD cases and control groups with respect to mean age at death (F5,146 = 99.1, p < 0.001) with patients with sLOAD, and controls, all (by definition) dying at a later age (p < 0.001) than patients with APPdup and missense APP mutations, sEOAD and individuals with DS.