APP and Dravet syndrome: However, overall severity of CAA did vary significantly across subtypes for DS (χ2 = 13.0, p < 0.001), sEOAD (χ2 = 13.1, p = 0.001) and sLOAD (χ2 = 14.4, p < 0.001), but not for patients with APPdup or missense APP mutation, or controls.