Similarly, despite reports suggesting that adipose tissue Lrp1 may be implicated in diet-induced obesity[54], more recent work showed that in the aP2-cre mouse, significant Cre activity is also found in ganglia of the peripheral nervous system (PNS), in adrenal medulla and in neurons throughout the CNS, proving that the aP2-cre mouse should no longer be used as a tool for adipose-tissue specific inactivation of genes[55–56]. Here, LRP1 is linked to obesity due to melanocortin 4 receptor deficiency.