In agreement with our results, a very elegant study employing conditional apoe deletion mouse models showed that deletion of WAT-expressed apoe had no effect on morbid obesity while deletion of hepatically-expressed apoe resulted in rather higher adipocity in mice[66], confirming the protective role of hepatically expressed APOE3 in obesity that we identified in our recently published work[57]. The gene discussed is APOE; the disease is obesity due to melanocortin 4 receptor deficiency.