We created a recombinant APOE form termed APOE4mut1 (apoE4 [L261A, W264A, F265A, L268A, V269A]) that in mice corrects hypercholesterolemia without triggering hypertriglyceridemia even at concentration as high as 170 mg/dL[68] (Fig. 2). This evidence concerns the gene APOE and Hypercholesterolemia.