In fact, virtually all genes associated with dystonia in spontaneous mutants (tottering, stargazer, ophisthotonus, ducky, lethargic, waddles, and wriggle) are involved in Purkinje cell Ca2+ signaling (Canca1a, Cacng2, Itpr1, Cacna2d2, Cacnb4, and Pmca2). This evidence concerns the gene CACNA2D2 and Dystonia.