CPN1 and hyperlipidemia: As it is said that Cpn acts in cooperation with hyperlipidaemia it seems that the effect of hyperlipidaemia in ApoB100only/LDLR−/− mice can be aggravated by Cpn infection but Cpn does not exacerbate atherosclerosis further in the presence of high-fat/high-cholesterol diet [43–45].