AKT1 and brain ischemia: At present, the regulatory role of phosphoinositide 3-kinase (PI3K)/serine-threonine protein kinase (Akt) signaling pathway in neuronal apoptosis after cerebral ischemia has attracted much attention, and 3-inositol phosphate dependent protein kinase-1 (PDK1) enhances its activity by phosphorylating Akt [4].