HIF1A and ovarian cancer: Assessing the expression levels of these three proteins in tumor samples and normal specimens, we found that 62.9%, 60%, and 54.7% ovarian cancer tissue specimens were positive for AEG-1, HIF-1α, and VEGF, respectively, for only 5%, 5%, and 10% obtained in normal ovarian tissue samples, respectively (all p < 0.001) (Table 1).