ACHE and Alzheimer disease: Many AD target proteins have previously been validated, including AchE (Yiannopoulou & Papageorgiou, 2013), BchE (Darvesh, 2016; Mushtaq et al., 2014), RAGE (Cai et al., 2016; Deane, 2012), TNF-alpha ((Leszek et al., 2016); (Wyss-Coray & Rogers, 2012), PLA2 (Gentile et al., 2012; Lee et al., 2011) and others.