ROS activate NF-κB, TNF-α, and STAT3 signaling pathways in inflammatory cells and tumor cells to release TNF, NOX2, IL-6, IL-2, IL-8, and CXCL12 involved in the change of TME [23, 27] (summarized in Figure 2 and Table 1). The gene discussed is NFKB1; the disease is neoplasm.