PLAT and susceptibility to pneumonia measurement: In terms of clinical trials, a randomized, multicenter trial (ICTuS-L) found that mild IV tPA combined with hypothermia by endovascular medication using meperidine and buspirone after whole infusion of tPA had no benefit in terms of favorable outcomes at 90 days compared to IV tPA alone, and pneumonia was found more frequently in the hypothermia group [162].