Flavonoid modulation of AQPs has been reported to ameliorate forms of cerebral and retinal edemas of different origins (AQP4) [132–135], lung injuries (AQP1) [136], and Sjögren syndrome-associated xerostomia (AQP5) [137], to inhibit ovarian tumor growth (AQP5) [89] and protect against UV-induced skin damage (AQP3) [63]. The gene discussed is AQP5; the disease is Sjogren syndrome.