In addition, there are two phase I/II clinical trials investigating the safety and activity of T cell transduction with an affinity-enhanced T cell receptor (TCR) for NY-ESO-1 and LAGE-1 (NY-ESO-1c259 T cells) in patients with relapsed or advanced multiple myeloma (NCT01892293, NCT01352286, Table 2). The gene discussed is CTAG1B; the disease is AL amyloidosis.