In the case of patients suffering from the rare hereditary disease Epidermodysplasia verruciformis (EV), mutations within at least two genes of homologous transmembrane channel-like (TMC) proteins, TMC6 (EVER1) and TMC8 (EVER2) were described (Lazarczyk et al., 2009, 2012). The gene discussed is TMC6; the disease is epidermodysplasia verruciformis.